Since 7yrs old to 24yrs old I have had severe migraines. I constantly took excedrine migraine and it got to the point where I was taking a whole bottle every 3 weeks for months! I called a doctor and asked how much of these pills can I take before it starts to hurt my liver or kidneys. She said 1,000mg is a gram and you can take up to 4g in 24hrs without hurting yourself. Just don't exceed 4g in a 24hr period. Well, I had a resonable doubt, but continued to take the pills anyways. I have a couple friends that are against taking pills for anything! When they are around and say they are getting a headache, I would always ask if they wanted a couple excedrine migraine and they would always say NO! I just didn't understand!!! All I could think about was the pain I get when I get migraines and I wouldn't wish that pain upon anyone! I thought they were crazy! I mean, if ya have pain in your head or anywhere else why not get rid of it right!? Well, my bestfriend and I talked about migraines alot and she would tell me she hardly gets headaches and i'd tell her i'm the complete oposite! Which she already knew :) So one day I had an epiphany. I thought "Well, she dosn't take medication and hardly gets them - I on the other hand take medications and always get them. So I decided to put my foot down and see if I could beat this for myself! I told myself, the next oncome of a migraine I was NOT going to take any meds atall what so ever! So of course I got one and I followed through with my goal. The worst pain ever!!! I'd say worse than child birth. But thats just me. Well it came and went after a couple days. I struggled so bad of course. So after that one I followed through many more of them without taking pills and slowly noticed that my migraines were less frequent and less severe. The funny thing is that now if im really in need of a pill (at work) I am able to take 1 tylenol and BAM it goes away! I was never able to take anything less than excedrin migrain before. I really pay attention to limit taking pills cause I don't want my body to become immune to it or adverse effects. It worked for me and I hope it can work for you. I know there are many reasons behind migraines but I highly recommend trying it.